Precision environmental health monitoring by longitudinal exposome and multi-omics profiling

Abstract

Conventional environmental health studies have primarily focused on limited environmental stressors at the population level, which lacks the power to dissect the complexity and heterogeneity of individualized environmental exposures. Here, as a pilot case study, we integrated deep-profiled longitudinal personal exposome and internal multi-omics to systematically investigate how the exposome shapes a single individual’s phenome. We annotated thousands of chemical and biological components in the personal exposome cloud and found they were significantly correlated with thousands of internal biomolecules, which was further cross-validated using corresponding clinical data. Our results showed that agrochemicals and fungi predominated in the highly diverse and dynamic personal exposome, and the biomolecules and pathways related to the individual’s immune system, kidney, and liver were highly …

Publication
Genome Research
Prof. Peng Gao
Prof. Peng Gao
Assistant Professor
Xiaotao SHEN/申小涛
Xiaotao SHEN/申小涛
Nanyang Assistant Professor

Metabolomics, Multi-omics, Bioinformatics, Systems Biology.

Prof. Chao Jiang
Prof. Chao Jiang
Assistant Professor
Prof. Sai Zhang
Prof. Sai Zhang
Assistant Professor